Class-specific histone/protein deacetylase inhibition protects against renal ischemia reperfusion injury and fibrosis formation.
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ABSTRACT:
SUBMITTER: Levine MH
PROVIDER: S-EPMC5493154 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
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Class-specific histone/protein deacetylase inhibition protects against renal ischemia reperfusion injury and fibrosis formation.
Levine M H MH Wang Z Z Bhatti T R TR Wang Y Y Aufhauser D D DD McNeal S S Liu Y Y Cheraghlou S S Han R R Wang L L Hancock W W WW
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20150223 4
Renal ischemia-reperfusion injury (IRI) is a common cause of renal dysfunction and renal failure. Histone/protein deacetylases (HDACs) regulate gene accessibility and higher order protein structures and may alter cellular responses to a variety of stresses. We investigated whether use of pan- and class-specific HDAC inhibitors (HDACi) could improve IRI tolerance in the kidney. Using a model of unilateral renal IRI, we investigated early renal function after IRI, and calculated fibrosis after IRI ...[more]
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