Ontology highlight
ABSTRACT:
SUBMITTER: Queenan BN
PROVIDER: S-EPMC5493445 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Queenan B N BN Lee K J KJ Tan H H Huganir R L RL Vicini S S Pak D T S DT
Neuroscience 20151214
When chronically silenced, cortical and hippocampal neurons homeostatically upregulate excitatory synaptic function. However, the subcellular position of such changes on the dendritic tree is not clear. We exploited the cable-filtering properties of dendrites to derive a parameter, the dendritic filtering index (DFI), to map the spatial distribution of synaptic currents. Our analysis indicates that young rat cortical neurons globally scale AMPA receptor-mediated currents, while mature hippocampa ...[more]