Unknown

Dataset Information

0

Mapping homeostatic synaptic plasticity using cable properties of dendrites.


ABSTRACT: When chronically silenced, cortical and hippocampal neurons homeostatically upregulate excitatory synaptic function. However, the subcellular position of such changes on the dendritic tree is not clear. We exploited the cable-filtering properties of dendrites to derive a parameter, the dendritic filtering index (DFI), to map the spatial distribution of synaptic currents. Our analysis indicates that young rat cortical neurons globally scale AMPA receptor-mediated currents, while mature hippocampal neurons do not, revealing distinct homeostatic strategies between brain regions and developmental stages. The DFI presents a useful tool for mapping the dendritic origin of synaptic currents and the location of synaptic plasticity changes.

SUBMITTER: Queenan BN 

PROVIDER: S-EPMC5493445 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature

altmetric image

Publications

Mapping homeostatic synaptic plasticity using cable properties of dendrites.

Queenan B N BN   Lee K J KJ   Tan H H   Huganir R L RL   Vicini S S   Pak D T S DT  

Neuroscience 20151214


When chronically silenced, cortical and hippocampal neurons homeostatically upregulate excitatory synaptic function. However, the subcellular position of such changes on the dendritic tree is not clear. We exploited the cable-filtering properties of dendrites to derive a parameter, the dendritic filtering index (DFI), to map the spatial distribution of synaptic currents. Our analysis indicates that young rat cortical neurons globally scale AMPA receptor-mediated currents, while mature hippocampa  ...[more]

Similar Datasets

| S-EPMC3136313 | biostudies-other
| S-EPMC4141722 | biostudies-literature
| S-EPMC3657766 | biostudies-literature
| S-EPMC4133507 | biostudies-literature
| S-EPMC4020085 | biostudies-other
| S-EPMC5907800 | biostudies-literature
| S-EPMC2634746 | biostudies-literature
| S-EPMC3310180 | biostudies-literature
| S-EPMC4739747 | biostudies-literature
| S-EPMC6250423 | biostudies-literature