Ontology highlight
ABSTRACT:
SUBMITTER: Van der Hoek KH
PROVIDER: S-EPMC5493656 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Van der Hoek Kylie H KH Eyre Nicholas S NS Shue Byron B Khantisitthiporn Onruedee O Glab-Ampi Kittirat K Carr Jillian M JM Gartner Matthew J MJ Jolly Lachlan A LA Thomas Paul Q PQ Adikusuma Fatwa F Jankovic-Karasoulos Tanja T Roberts Claire T CT Helbig Karla J KJ Beard Michael R MR
Scientific reports 20170630 1
Zika virus (ZIKV) infection has emerged as a global health threat and infection of pregnant women causes intrauterine growth restriction, spontaneous abortion and microcephaly in newborns. Here we show using biologically relevant cells of neural and placental origin that following ZIKV infection, there is attenuation of the cellular innate response characterised by reduced expression of IFN-β and associated interferon stimulated genes (ISGs). One such ISG is viperin that has well documented anti ...[more]