Ontology highlight
ABSTRACT:
SUBMITTER: Ball CR
PROVIDER: S-EPMC5494525 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
EMBO molecular medicine 20170701 7
Although tumor-initiating cell (TIC) self-renewal has been postulated to be essential in progression and metastasis formation of human pancreatic adenocarcinoma (PDAC), clonal dynamics of TICs within PDAC tumors are yet unknown. Here, we show that long-term progression of PDAC in serial xenotransplantation is driven by a succession of transiently active TICs producing tumor cells in temporally restricted bursts. Clonal tracking of individual, genetically marked TICs revealed that individual tumo ...[more]