Dataset Information

A Meta-Analysis of Choroidal Thickness Changes in Unilateral Amblyopia.

ABSTRACT:

Purpose

To date, the topic of amblyopic changes remains controversial. Therefore, a systematic review and meta-analysis were carried out to evaluate choroidal changes in unilateral amblyopia.

Methods

Major literature databases were searched for amblyopia-relevant studies. Using enhanced depth imaging optical coherence tomography (EDI-OCT), the primary outcome parameters examined were subfoveal choroidal thickness (SFCT) and different choroidal thickness (CT) positions. Efficacy estimates were evaluated by weighted mean difference (WMD) and 95% confidence interval (CI) for choroidal-associated changes. We performed subgroup analysis and metaregression analysis to examine potential sources of heterogeneity.

Results

Eleven cross-sectional studies that included a total of 768 participants were identified. The amblyopic eye SFCT was thicker than that of the fellow and control (normal) eyes (WMD_{amblyopia?versus?fellow} = 49.24, 95% CI of 30.22 to 68.27, p < 0.001; WMD_{amblyopia?versus?control} = 54.51, 95% CI of 32.17 to 76.85, p < 0.001). There were no differences between the fellow and control eyes (WMD = 13.81, 95% CI of 1.16 to 28.77, p = 0.071). Subgroup and metaregression analyses indicated that the OCT type was the main source of heterogeneity.

Conclusions

The CT in the amblyopic eyes was thicker than that in the fellow and control eyes.

SUBMITTER: Liu Y

PROVIDER: S-EPMC5494565 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Publications

A Meta-Analysis of Choroidal Thickness Changes in Unilateral Amblyopia.

Liu Yanli Y Dong Yi Y Zhao Kanxing K

Journal of ophthalmology 20170619

<h4>Purpose</h4>To date, the topic of amblyopic changes remains controversial. Therefore, a systematic review and meta-analysis were carried out to evaluate choroidal changes in unilateral amblyopia.<h4>Methods</h4>Major literature databases were searched for amblyopia-relevant studies. Using enhanced depth imaging optical coherence tomography (EDI-OCT), the primary outcome parameters examined were subfoveal choroidal thickness (SFCT) and different choroidal thickness (CT) positions. Efficacy es ...[more]

PMID: 28751980

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Project description:Background and Objectives: Patients with cataract and age-related macular degeneration (AMD) may safely undergo cataract phacoemulsification to enhance visual acuity. Although it has not been proven that cataract surgery can cause AMD progression, different phacoemulsification effects are observed not only on retinal but also on choroidal tissues. The purpose of this study was to evaluate the effect of phacoemulsification on the choroidal thickness (CT) in eyes with and without AMD. Materials and Methods: In 32 eyes of 32 patients with senile cataract (No-AMD group) and in 32 eyes of 32 patients with cataract and dry AMD (AMD group), who had phacoemulsification without intraoperative complications and intraocular lens implantation, foveal retinal thickness (FRT) and CT were evaluated three times: at 1-2 post meridiem preoperatively, then 1 month and 3 months postoperatively, using 1050 nm swept source-optical coherence tomography (Topcon, Tokyo, Japan). Results: In both groups, a significant increase in FRT was observed after one month and a decrease after three months without reaching the baseline. One month after surgery, a sectorial CT increase was apparent in all sectors in both groups. A negative association between CT and age was disclosed in the No-AMD group almost for all regions at all time points. Furthermore, CT was significantly negatively associated with axial length (AL) in all sectors at all time points in the AMD group. Conclusion: Uneventful phacoemulsification may induce changes in the posterior eye segment. An increase in CT and FRT was observed in both groups one month after the surgery. However, three months after surgery, CT changes were different in both groups, while FRT decreased in both groups. CT changes negatively associated with age in the No-AMD group and with AL in the AMD eyes. These postoperative changes in the choroid and retina may not only lead to the late-onset pseudophakic cystoid macular edema but also to progression of AMD.

Dataset Information

A Meta-Analysis of Choroidal Thickness Changes in Unilateral Amblyopia.

Purpose

Methods

Results

Conclusions

Publications

A Meta-Analysis of Choroidal Thickness Changes in Unilateral Amblyopia.

Similar Datasets

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