Ontology highlight
ABSTRACT:
SUBMITTER: Corrales M
PROVIDER: S-EPMC5495067 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Corrales Marc M Rosado Aránzazu A Cortini Ruggero R van Arensbergen Joris J van Steensel Bas B Filion Guillaume J GJ
Genome research 20170418 7
Housekeeping genes of animal genomes cluster in the same chromosomal regions. It has long been suggested that this organization contributes to their steady expression across all the tissues of the organism. Here, we show that the activity of <i>Drosophila</i> housekeeping gene promoters depends on the expression of their neighbors. By measuring the expression of ∼85,000 reporters integrated in Kc167 cells, we identified the best predictors of expression as chromosomal contacts with the promoters ...[more]