Stroke Onset Time Determination Using MRI Relaxation Times without Non-Ischaemic Reference in A Rat Stroke Model.

ABSTRACT:

Background

Objective timing of stroke in emergency departments is expected to improve patient stratification. Magnetic resonance imaging (MRI) relaxations times, T₂ and T_1ρ , in abnormal diffusion delineated ischaemic tissue were used as proxies of stroke time in a rat model.

Methods

Both 'non-ischaemic reference'-dependent and -independent estimators were generated. Apparent diffusion coefficient (ADC), T₂ and T_1ρ , were sequentially quantified for up to 6 hours of stroke in rats (n = 8) at 4.7T. The ischaemic lesion was identified as a contiguous collection of voxels with low ADC. T₂ and T_1ρ in the ischaemic lesion and in the contralateral non-ischaemic brain tissue were determined. Diff

SUBMITTER: Norton TJT 

PROVIDER: S-EPMC5495158 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature