Critical periods and growth patterns from fetal life onwards associated with childhood insulin levels.

ABSTRACT:

Aims/hypothesis

We aimed to identify critical periods and specific longitudinal growth patterns from fetal life onwards associated with childhood insulin and C-peptide levels.

Methods

In a prospective population-based cohort study of 4328 children, we repeatedly measured (femur) length and (estimated fetal) weight from the second trimester of fetal life until 6 years of age. BMI was calculated from 6 months onwards. Insulin and C-peptide levels were measured at 6 years of age.

Results

Preterm birth and small or large size for gestational age at birth were not associated with childhood insulin levels. Conditional growth modelling showed that, independent of growth in other time intervals, weight growth in each time interval from birth onwards, length growth from 6 mont

SUBMITTER: Voerman E 

PROVIDER: S-EPMC5495163 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature