Ontology highlight
ABSTRACT:
SUBMITTER: Hamilton N
PROVIDER: S-EPMC5495464 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Critical reviews in oncogenesis 20150101 5-6
Triple-negative breast cancers (TNBCs) lack estrogen receptor-α (ERα), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER2) amplification and account for almost half of all breast cancer deaths. This breast cancer subtype largely affects women who are premenopausal, African-American, or have BRCA1/2 mutations. Women with TNBC are plagued with higher rates of distant metastasis that significantly diminish their overall survival and quality of life. Due to their poor res ...[more]