Ontology highlight
ABSTRACT:
SUBMITTER: Wu D
PROVIDER: S-EPMC5495571 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Wu David D Huang Ru-Ting RT Hamanaka Robert B RB Krause Matt M Oh Myung-Jin MJ Kuo Cheng-Hsiang CH Nigdelioglu Recep R Meliton Angelo Y AY Witt Leah L Dai Guohao G Civelek Mete M Prabhakar Nanduri R NR Fang Yun Y Mutlu Gökhan M GM
eLife 20170530
Hemodynamic forces regulate vascular functions. Disturbed flow (DF) occurs in arterial bifurcations and curvatures, activates endothelial cells (ECs), and results in vascular inflammation and ultimately atherosclerosis. However, how DF alters EC metabolism, and whether resulting metabolic changes induce EC activation, is unknown. Using transcriptomics and bioenergetic analysis, we discovered that DF induces glycolysis and reduces mitochondrial respiratory capacity in human aortic ECs. DF-induced ...[more]