Ontology highlight
ABSTRACT:
SUBMITTER: Bergeron LJ
PROVIDER: S-EPMC549572 | biostudies-literature | 2005
REPOSITORIES: biostudies-literature
Bergeron Lucien Junior LJ Perreault Jean-Pierre JP
Nucleic acids research 20050224 4
Ribozymes, RNA molecules that catalyze the cleavage of RNA substrates, provide an interesting alternative to the RNA interference (RNAi) approach to gene inactivation, especially given the fact that RNAi seems to trigger an immunological response. Unfortunately, the limited substrate specificity of ribozymes is considered to be a significant hurdle in their development as molecular tools. Here, we report the molecular engineering of a ribozyme possessing a new biosensor module that switches the ...[more]