Ontology highlight
ABSTRACT:
SUBMITTER: Janssen AWF
PROVIDER: S-EPMC5496037 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Janssen Aafke W F AWF Houben Tom T Katiraei Saeed S Dijk Wieneke W Boutens Lily L van der Bolt Nieke N Wang Zeneng Z Brown J Mark JM Hazen Stanley L SL Mandard Stéphane S Shiri-Sverdlov Ronit R Kuipers Folkert F Willems van Dijk Ko K Vervoort Jacques J Stienstra Rinke R Hooiveld Guido J E J GJEJ Kersten Sander S
Journal of lipid research 20170522 7
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide, yet the pathogenesis of NAFLD is only partially understood. Here, we investigated the role of the gut bacteria in NAFLD by stimulating the gut bacteria via feeding mice the fermentable dietary fiber, guar gum (GG), and suppressing the gut bacteria via chronic oral administration of antibiotics. GG feeding profoundly altered the gut microbiota composition, in parallel with reduced diet-induced obesity and improve ...[more]