Ontology highlight
ABSTRACT:
SUBMITTER: Kim DS
PROVIDER: S-EPMC5496043 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Kim Daniel Seung DS Jackson Anne U AU Li Yatong K YK Stringham Heather M HM Kuusisto Johanna J Kangas Antti J AJ Soininen Pasi P Ala-Korpela Mika M Burant Charles F CF Salomaa Veikko V Boehnke Michael M Laakso Markku M Speliotes Elizabeth K EK
Journal of lipid research 20170524 7
A glutamate-to-lysine variant (rs58542926-T) in transmembrane 6 superfamily member 2 (<i>TM6SF2</i>) is associated with increased fatty liver disease and diabetes in conjunction with decreased cardiovascular disease risk. To identify mediators of the effects of <i>TM6SF2</i>, we tested for associations between rs58542926-T and serum lipoprotein/metabolite measures in cross-sectional data from nondiabetic statin-naïve participants. We identified independent associations between rs58542926-T and a ...[more]