Ontology highlight
ABSTRACT:
SUBMITTER: Yang X
PROVIDER: S-EPMC5496229 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Yang Xingyan X Shen Quankuan Q Sulaiman Xierzhatijiang X Liu Hequn H Peng Minsheng M Zhang Yaping Y
Hereditas 20170703
Preaxial polydactyly (PPD) is congenital hand malformation characterized by the duplication of digit. Herein, we scan the genome-wide SNPs for a large Chinese family with PPD-II/III. We employ the refined IBD algorithm to identify the identity-by-decent (IBD) segments and compare the frequency among the patients and normal relatives. A total of 72 markers of 0.01 percentile of the permutation are identified as the peak signals. Among of them, 57markers locate on chromosome 7q36 which is associat ...[more]