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Analysis of the KIFAP3 gene in amyotrophic lateral sclerosis: a multicenter survival study.

ABSTRACT: Sporadic amyotrophic lateral sclerosis is a multifactorial disease of environmental and genetic origin. In a previous large multicenter genome wide study, common genetic variation in the Kinesin-Associated Protein 3 (KIFAP3) gene (rs1541160) was reported to have a significant effect on survival in amyotrophic lateral sclerosis patients. However, this could not be replicated in 3 smaller independent cohorts. We conducted a large multicenter multivariate survival analysis (n = 2362) on the effect of genetic variation in rs1541160. The previously reported beneficial genotype did not show a significant improvement in survival in this patient group.

SUBMITTER: van Doormaal PT 

PROVIDER: S-EPMC5496711 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature

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Analysis of the KIFAP3 gene in amyotrophic lateral sclerosis: a multicenter survival study.

van Doormaal Perry T C PT   Ticozzi Nicola N   Gellera Cinzia C   Ratti Antonia A   Taroni Franco F   Chiò Adriano A   Calvo Andrea A   Mora Gabriele G   Restagno Gabriella G   Traynor Bryan J BJ   Birve Anna A   Lemmens Robin R   van Es Michael A MA   Saris Christiaan G J CG   Blauw Hylke M HM   van Vught Paul W J PW   Groen Ewout J N EJ   Corrado Lucia L   Mazzini Letizia L   Del Bo Roberto R   Corti Stefania S   Waibel Stefan S   Meyer Thomas T   Ludolph Albert C AC   Goris An A   van Damme Philip P   Robberecht Wim W   Shatunov Aleksey A   Fogh Isabella I   Andersen Peter M PM   D'Alfonso Sandra S   Hardiman Orla O   Cronin Simon S   Rujescu Dan D   Al-Chalabi Ammar A   Landers John E JE   Silani Vincenzo V   van den Berg Leonard H LH   Veldink Jan H JH  

Neurobiology of aging 20140419 10

Sporadic amyotrophic lateral sclerosis is a multifactorial disease of environmental and genetic origin. In a previous large multicenter genome wide study, common genetic variation in the Kinesin-Associated Protein 3 (KIFAP3) gene (rs1541160) was reported to have a significant effect on survival in amyotrophic lateral sclerosis patients. However, this could not be replicated in 3 smaller independent cohorts. We conducted a large multicenter multivariate survival analysis (n = 2362) on the effect  ...[more]

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