Ontology highlight
ABSTRACT:
SUBMITTER: Buisson R
PROVIDER: S-EPMC5496772 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Buisson Rémi R Niraj Joshi J Rodrigue Amélie A Ho Chu Kwen CK Kreuzer Johannes J Foo Tzeh Keong TK Hardy Emilie J-L EJ Dellaire Graham G Haas Wilhelm W Xia Bing B Masson Jean-Yves JY Zou Lee L
Molecular cell 20170112 2
ATR is a key regulator of cell-cycle checkpoints and homologous recombination (HR). Paradoxically, ATR inhibits CDKs during checkpoint responses, but CDK activity is required for efficient HR. Here, we show that ATR promotes HR after CDK-driven DNA end resection. ATR stimulates the BRCA1-PALB2 interaction after DNA damage and promotes PALB2 localization to DNA damage sites. ATR enhances BRCA1-PALB2 binding at least in part by inhibiting CDKs. The optimal interaction of BRCA1 and PALB2 requires p ...[more]