Ontology highlight
ABSTRACT:
SUBMITTER: Posavad CM
PROVIDER: S-EPMC5496807 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Posavad C M CM Zhao L L Dong L L Jin L L Stevens C E CE Magaret A S AS Johnston C C Wald A A Zhu J J Corey L L Koelle D M DM
Mucosal immunology 20170104 5
Local mucosal cellular immunity is critical in providing protection from HSV-2. To characterize and quantify HSV-2-reactive mucosal T cells, lymphocytes were isolated from endocervical cytobrush and biopsy specimens from 17 HSV-2-infected women and examined ex vivo for the expression of markers associated with maturation and tissue residency and for functional T-cell responses to HSV-2. Compared with their circulating counterparts, cervix-derived CD4+ and CD8+ T cells were predominantly effector ...[more]