Ontology highlight
ABSTRACT:
SUBMITTER: Ji YW
PROVIDER: S-EPMC5496813 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Ji Y W YW Mittal S K SK Hwang H S HS Chang E-J EJ Lee J H JH Seo Y Y Yeo A A Noh H H Lee H S HS Chauhan S K SK Lee H K HK
Mucosal immunology 20170104 5
Inflammatory damage of mucosal surface of the eye is a hallmark of dry eye disease (DED) and, in severe cases, can lead to significant discomfort, visual impairment, and blindness. DED is a multifactorial autoimmune disorder with a largely unknown pathogenesis. Using a cross-sectional patient study and a well-characterized murine model of DED, herein we investigated the immunoregulatory function of interleukin-22 (IL-22) in the pathogenesis of DED. We found that IL-22 levels were elevated in lac ...[more]