Peripheral Zone Inflammation Is Not Strongly Associated With Lower Urinary Tract Symptom Incidence and Progression in the Placebo Arm of the Prostate Cancer Prevention Trial?.

ABSTRACT: Intraprostatic inflammation has been associated with lower urinary tract symptom (LUTS) progression. However, prior studies used tissue removed for clinical indications, potentially skewing inflammation extent or biasing the association. We, therefore, evaluated inflammation and LUTS incidence and progression in men who underwent biopsy of the prostate peripheral zone irrespective of indication.We developed nested case-control sets in men in the placebo arm of the Prostate Cancer Prevention Trial who were free of clinical BPH and had a protocol-directed year 7 biopsy. Cases had baseline IPSS <15 and year 7 IPSS of 8-14 (low, N?=?47), 15-19 (incident moderate, N?=?42), or ?20 (incident high, N?=?44). Controls had baseline and year 7 IPSS <8 (N?=?41). For progression from IPSS <8, cases had baseline to year 7 IPSS slope >75th percentile (N?=?46) and controls had a slope <25th percentile (N?=?45). For progression from IPSS?=?8-14, cases had a slope >75th percentile (N?=?46) and controls had a slope?<25th percentile (N?=?46). We reviewed three H&E-stained biopsy cores per man to determine prevalence of ?1 core with inflammation and mean extent (%) of tissue area with inflammation.Inflammation prevalence in low cases (64%) was similar to controls (66%), but higher in moderate (69%) and high (73%) cases (P-trend?=?0.4). Extent did not differ across LUTS categories (P-trend?=?0.5). For progression from IPSS?

SUBMITTER: Kulac I 

PROVIDER: S-EPMC5497457 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature