Ontology highlight
ABSTRACT:
SUBMITTER: Boyken SE
PROVIDER: S-EPMC5497568 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Boyken Scott E SE Chen Zibo Z Groves Benjamin B Langan Robert A RA Oberdorfer Gustav G Ford Alex A Gilmore Jason M JM Xu Chunfu C DiMaio Frank F Pereira Jose Henrique JH Sankaran Banumathi B Seelig Georg G Zwart Peter H PH Baker David D
Science (New York, N.Y.) 20160501 6286
In nature, structural specificity in DNA and proteins is encoded differently: In DNA, specificity arises from modular hydrogen bonds in the core of the double helix, whereas in proteins, specificity arises largely from buried hydrophobic packing complemented by irregular peripheral polar interactions. Here, we describe a general approach for designing a wide range of protein homo-oligomers with specificity determined by modular arrays of central hydrogen-bond networks. We use the approach to des ...[more]