Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish.
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ABSTRACT:
SUBMITTER: Geudens I
PROVIDER: S-EPMC5497575 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Publications
Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish.
Geudens Ilse I Herpers Robert R Hermans Karlien K Segura Inmaculada I Ruiz de Almodovar Carmen C Bussmann Jeroen J De Smet Frederik F Vandevelde Wouter W Hogan Benjamin M BM Siekmann Arndt A Claes Filip F Moore John C JC Pistocchi Anna Silvia AS Loges Sonja S Mazzone Massimiliano M Mariggi Giovanni G Bruyère Françoise F Cotelli Franco F Kerjaschki Dontscho D Noël Agnes A Foidart Jean-Michel JM Gerhardt Holger H Gerhardt Holger H Ny Annelii A Langenberg Tobias T Lawson Nathan D ND Duckers Henricus J HJ Schulte-Merker Stefan S Carmeliet Peter P Dewerchin Mieke M
Arteriosclerosis, thrombosis, and vascular biology 20100513 9
<h4>Objective</h4>To study whether Notch signaling, which regulates cell fate decisions and vessel morphogenesis, controls lymphatic development.<h4>Methods and results</h4>In zebrafish embryos, sprouts from the axial vein have lymphangiogenic potential because they give rise to the first lymphatics. Knockdown of delta-like-4 (Dll4) or its receptors Notch-1b or Notch-6 in zebrafish impaired lymphangiogenesis. Dll4/Notch silencing reduced the number of sprouts producing the string of parchordal l ...[more]
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