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Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish.

ABSTRACT: To study whether Notch signaling, which regulates cell fate decisions and vessel morphogenesis, controls lymphatic development.In zebrafish embryos, sprouts from the axial vein have lymphangiogenic potential because they give rise to the first lymphatics. Knockdown of delta-like-4 (Dll4) or its receptors Notch-1b or Notch-6 in zebrafish impaired lymphangiogenesis. Dll4/Notch silencing reduced the number of sprouts producing the string of parchordal lymphangioblasts; instead, sprouts connecting to the intersomitic vessels were formed. At a later phase, Notch silencing impaired navigation of lymphatic intersomitic vessels along their arterial templates.These studies imply critical roles for Notch signaling in the formation and wiring of the lymphatic network.

SUBMITTER: Geudens I 

PROVIDER: S-EPMC5497575 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature

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Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish.

Geudens Ilse I   Herpers Robert R   Hermans Karlien K   Segura Inmaculada I   Ruiz de Almodovar Carmen C   Bussmann Jeroen J   De Smet Frederik F   Vandevelde Wouter W   Hogan Benjamin M BM   Siekmann Arndt A   Claes Filip F   Moore John C JC   Pistocchi Anna Silvia AS   Loges Sonja S   Mazzone Massimiliano M   Mariggi Giovanni G   Bruyère Françoise F   Cotelli Franco F   Kerjaschki Dontscho D   Noël Agnes A   Foidart Jean-Michel JM   Gerhardt Holger H   Gerhardt Holger H   Ny Annelii A   Langenberg Tobias T   Lawson Nathan D ND   Duckers Henricus J HJ   Schulte-Merker Stefan S   Carmeliet Peter P   Dewerchin Mieke M  

Arteriosclerosis, thrombosis, and vascular biology 20100513 9

<h4>Objective</h4>To study whether Notch signaling, which regulates cell fate decisions and vessel morphogenesis, controls lymphatic development.<h4>Methods and results</h4>In zebrafish embryos, sprouts from the axial vein have lymphangiogenic potential because they give rise to the first lymphatics. Knockdown of delta-like-4 (Dll4) or its receptors Notch-1b or Notch-6 in zebrafish impaired lymphangiogenesis. Dll4/Notch silencing reduced the number of sprouts producing the string of parchordal l  ...[more]