Unknown

Dataset Information

0

Supplementation of Low- and High-fat Diets with Fermentable Fiber Exacerbates Severity of DSS-induced Acute Colitis.


ABSTRACT: Lack of dietary fiber has been suggested to increase the risk of developing various chronic inflammatory diseases, whereas supplementation of diets with fiber might offer an array of health-promoting benefits. Consistent with this theme, we recently reported that in mice, compositionally defined diets that are made with purified ingredients and lack fermentable fiber promote low-grade inflammation and metabolic syndrome, both of which could be ameliorated by supplementation of such diets with the fermentable fiber inulin.Herein, we examined if, relative to a grain-based mouse diet (chow), compositionally defined diet consumption would impact development of intestinal inflammation induced by dextran sulfate sodium (DSS) and moreover, whether DSS-induced colitis might also be attenuated by diets supplemented with inulin.Analogous to their promotion of low-grade inflammation, compositionally defined diet of high- and low-fat content with cellulose increased the severity of DSS-induced colitis relative to chow. However, in contrast to the case of low-grade inflammation, addition of inulin, but not the insoluble fiber cellulose, further exacerbated the severity of colitis and its associated clinical manifestations (weight loss and bleeding) in both low- and high-fat diets.While inulin, and perhaps other fermentable fibers, can ameliorate low-grade inflammation and associated metabolic disease, it also has the potential to exacerbate disease severity in response to inducers of acute colitis.

SUBMITTER: Miles JP 

PROVIDER: S-EPMC5497995 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

altmetric image

Publications

Supplementation of Low- and High-fat Diets with Fermentable Fiber Exacerbates Severity of DSS-induced Acute Colitis.

Miles Jennifer P JP   Zou Jun J   Kumar Matam-Vijay MV   Pellizzon Michael M   Ulman Edward E   Ricci Matthew M   Gewirtz Andrew T AT   Chassaing Benoit B  

Inflammatory bowel diseases 20170701 7


<h4>Background</h4>Lack of dietary fiber has been suggested to increase the risk of developing various chronic inflammatory diseases, whereas supplementation of diets with fiber might offer an array of health-promoting benefits. Consistent with this theme, we recently reported that in mice, compositionally defined diets that are made with purified ingredients and lack fermentable fiber promote low-grade inflammation and metabolic syndrome, both of which could be ameliorated by supplementation of  ...[more]

Similar Datasets

| S-EPMC9264660 | biostudies-literature
| S-EPMC6243010 | biostudies-literature
| S-EPMC5409669 | biostudies-literature
| S-EPMC4117732 | biostudies-literature
| S-EPMC7961925 | biostudies-literature
| S-EPMC4801899 | biostudies-other
| S-EPMC6185382 | biostudies-literature
| S-EPMC6461699 | biostudies-literature
| S-EPMC5966668 | biostudies-literature
| S-EPMC5264153 | biostudies-literature