Ontology highlight
ABSTRACT:
SUBMITTER: Wang JY
PROVIDER: S-EPMC5498112 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Wang Jun Yi JY Hessl David D Hagerman Randi J RJ Simon Tony J TJ Tassone Flora F Ferrer Emilio E Rivera Susan M SM
Neurobiology of aging 20170318
Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disorder typically affecting male premutation carriers with 55-200 CGG trinucleotide repeat expansions in the FMR1 gene after age 50. The aim of this study was to examine whether cerebellar and brainstem changes emerge during development or aging in late life. We retrospectively analyzed magnetic resonance imaging scans from 322 males (age 8-81 years). Volume changes in the cerebellum and brainstem were contras ...[more]