Ontology highlight
ABSTRACT:
SUBMITTER: Wang P
PROVIDER: S-EPMC5498114 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Wang Peng P Hong Gloria J GJ Wilson Matthew R MR Balskus Emily P EP
Journal of the American Chemical Society 20170216 8
The kinamycin family of aromatic polyketide natural products contains an atypical angucycline ring system substituted with a diazo group. The enzymatic chemistry involved in constructing both of these structural features has been largely unexplored. Here we report the in vivo and in vitro production of seongomycin, a shunt product from this pathway, and stealthin C, a proposed biosynthetic precursor to the kinamycins. We show that a single enzyme, the flavin-dependent monooxygenase AlpJ, can gen ...[more]