Ontology highlight
ABSTRACT:
SUBMITTER: Lee SJ
PROVIDER: S-EPMC5498145 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Lee Su Jin SJ Park Jeen Woo JW Kang Beom Sik BS Lee Dong-Seok DS Lee Hyun-Shik HS Choi Sooyoung S Kwon Oh-Shin OS
BMB reports 20170601 6
Although doxorubicin (Dox)-induced oxidative stress is known to be associated with cytotoxicity, the precise mechanism remains unclear. Genotoxic stress not only generates free radicals, but also affects actin cytoskeleton stability. We showed that Dox-induced RhoA signaling stimulated actin cytoskeleton alterations, resulting in central stress fiber disruption at early time points and cell periphery cortical actin formation at a later stage, in HeLa cells. Interestingly, activation of a cofilin ...[more]