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Self-Reported Questionnaire Detects Family History of Cancer in a Pancreatic Cancer Screening Program.

ABSTRACT: Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer death; approximately 5-10% of PDAC is hereditary. Self-administered health history questionnaires (HHQs) may provide a low-cost method to detail family history (FH) of malignancy. Pancreas Center patients were asked to enroll in a registry; 149 with PDAC completed a HHQ which included FH data. Patients with FH of PDAC, or concern for inherited PDAC syndrome, were separately evaluated in a Prevention Program and additionally met with a genetic counselor (GC) to assess PDAC risk (n?=?61). FH obtained through GC and HHQ were compared using Wilcoxon signed-rank sum and generalized linear mixed models with Poisson distribution. Agreement between GC and HHQ risk-assessment was assessed using kappa (?) statistic. In the Prevention Program, HHQ was as precise in detecting FH of cancer as the GC (all p?>?0.05). GC and HHQ demonstrated substantial agreement in risk-stratification of the Prevention Program cohort (??=?0.73, 95% CI 0.59-0.87.) The sensitivity of the HHQ to detect a patient at elevated risk (i.e., moderate- or high-risk) of PDAC, compared to GC, was 82.9% (95% CI 67.3-92.3%) with a specificity of 95% (95% CI 73.1-99.7%). However, seven patients who were classified as average-risk by the HHQ were found to be at an elevated-risk of PDAC by the GC. In the PDAC cohort, 30/149 (20.1%) reported at least one first-degree relative (FDR) with PDAC. The limited sensitivity of the HHQ to detect patients at elevated risk of PDAC in the Prevention Program cohort suggests that a GC adds value in risk-assessment in this population. The HHQ may offer an opportunity to identify high-risk patients in a PDAC population.

SUBMITTER: Lucas AL

PROVIDER: S-EPMC5498249 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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Self-Reported Questionnaire Detects Family History of Cancer in a Pancreatic Cancer Screening Program.

Lucas Aimee L AL Tarlecki Adam A Van Beck Kellie K Lipton Casey C RoyChoudhury Arindam A Levinson Elana E Kumar Sheila S Chung Wendy K WK Frucht Harold H Genkinger Jeanine M JM

Journal of genetic counseling 20161230 4

Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer death; approximately 5-10% of PDAC is hereditary. Self-administered health history questionnaires (HHQs) may provide a low-cost method to detail family history (FH) of malignancy. Pancreas Center patients were asked to enroll in a registry; 149 with PDAC completed a HHQ which included FH data. Patients with FH of PDAC, or concern for inherited PDAC syndrome, were separately evaluated in a Prevention Program and additionally met ...[more]

PMID: 28039657

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Dataset Information

Self-Reported Questionnaire Detects Family History of Cancer in a Pancreatic Cancer Screening Program.

Publications

Self-Reported Questionnaire Detects Family History of Cancer in a Pancreatic Cancer Screening Program.

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