Ontology highlight
ABSTRACT:
SUBMITTER: Nikolic J
PROVIDER: S-EPMC5498545 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Nikolic Jovan J Le Bars Romain R Lama Zoé Z Scrima Nathalie N Lagaudrière-Gesbert Cécile C Gaudin Yves Y Blondel Danielle D
Nature communications 20170705 1
Replication of Mononegavirales occurs in viral factories which form inclusions in the host-cell cytoplasm. For rabies virus, those inclusions are called Negri bodies (NBs). We report that NBs have characteristics similar to those of liquid organelles: they are spherical, they fuse to form larger structures, and they disappear upon hypotonic shock. Their liquid phase is confirmed by FRAP experiments. Live-cell imaging indicates that viral nucleocapsids are ejected from NBs and transported along m ...[more]