Ontology highlight
ABSTRACT:
SUBMITTER: Urakami A
PROVIDER: S-EPMC5498722 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Urakami Akane A Sakurai Atsuko A Ishikawa Momoko M Yap Moh Lan ML Flores-Garcia Yevel Y Haseda Yasunari Y Aoshi Taiki T Zavala Fidel P FP Rossmann Michael G MG Kuno Sachiko S Ueno Ryuji R Akahata Wataru W
Clinical and vaccine immunology : CVI 20170705 7
Virus-like particles (VLPs) are noninfectious multiprotein structures that are engineered to self-assemble from viral structural proteins. Here, we developed a novel VLP-based vaccine platform utilizing VLPs from the chikungunya virus. We identified two regions within the envelope protein, a structural component of chikungunya, where foreign antigens can be inserted without compromising VLP structure. Our VLP displays 480 copious copies of an inserted antigen on the VLP surface in a highly symme ...[more]