Ontology highlight
ABSTRACT:
SUBMITTER: O'Loughlin AJ
PROVIDER: S-EPMC5498810 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
O'Loughlin Aisling J AJ Mäger Imre I de Jong Olivier G OG Varela Miguel A MA Schiffelers Raymond M RM El Andaloussi Samir S Wood Matthew J A MJA Vader Pieter P
Molecular therapy : the journal of the American Society of Gene Therapy 20170406 7
Extracellular vesicles (EVs) are cell-derived, membranous nanoparticles that mediate intercellular communication by transferring biomolecules, including proteins and RNA, between cells. As a result of their suggested natural capability to functionally deliver RNA, EVs may be harnessed as therapeutic RNA carriers. One major limitation for their translation to therapeutic use is the lack of an efficient, robust, and scalable method to load EVs with RNA molecules of interest. Here, we evaluated and ...[more]