Ontology highlight
ABSTRACT:
SUBMITTER: Pearson RM
PROVIDER: S-EPMC5498834 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Pearson Ryan M RM Casey Liam M LM Hughes Kevin R KR Wang Leon Z LZ North Madeleine G MG Getts Daniel R DR Miller Stephen D SD Shea Lonnie D LD
Molecular therapy : the journal of the American Society of Gene Therapy 20170505 7
Polymeric nanoparticles (NPs) have demonstrated their potential to induce antigen (Ag)-specific immunological tolerance in multiple immune models and are at various stages of commercial development. Association of Ag with NPs is typically achieved through surface coupling or encapsulation methods. However, these methods have limitations that include high polydispersity, uncontrollable Ag loading and release, and possible immunogenicity. Here, using antigenic peptides conjugated to poly(lactide-c ...[more]