Ontology highlight
ABSTRACT:
SUBMITTER: Chen X
PROVIDER: S-EPMC5499527 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Chen Xu X Wu Qiuxia Q Depeille Philippe P Chen Peirong P Thornton Sophie S Kalirai Helen H Coupland Sarah E SE Roose Jeroen P JP Bastian Boris C BC
Cancer cell 20170501 5
Constitutive activation of Gαq signaling by mutations in GNAQ or GNA11 occurs in over 80% of uveal melanomas (UMs) and activates MAPK. Protein kinase C (PKC) has been implicated as a link, but the mechanistic details remained unclear. We identified PKC δ and ɛ as required and sufficient to activate MAPK in GNAQ mutant melanomas. MAPK activation depends on Ras and is caused by RasGRP3, which is significantly and selectively overexpressed in response to GNAQ/11 mutation in UM. RasGRP3 activation o ...[more]