Ontology highlight
ABSTRACT:
SUBMITTER: Montellese C
PROVIDER: S-EPMC5499762 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Montellese Christian C Montel-Lehry Nathalie N Henras Anthony K AK Kutay Ulrike U Gleizes Pierre-Emmanuel PE O'Donohue Marie-Françoise MF
Nucleic acids research 20170601 11
The poly-A specific ribonuclease (PARN), initially characterized for its role in mRNA catabolism, supports the processing of different types of non-coding RNAs including telomerase RNA. Mutations in PARN are linked to dyskeratosis congenita and pulmonary fibrosis. Here, we show that PARN is part of the enzymatic machinery that matures the human 18S ribosomal RNA (rRNA). Consistent with its nucleolar steady-state localization, PARN is required for 40S ribosomal subunit production and co-purifies ...[more]