Ontology highlight
ABSTRACT:
SUBMITTER: Schoenhals M
PROVIDER: S-EPMC5499840 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Cell cycle (Georgetown, Tex.) 20170502 11
Plasma cells (PCs) generation occurs in hypoxic conditions in vivo, whereas the relevance of O<sub>2</sub> pressure in PC differentiation remains unknown. Using our in vitro PC differentiation model, we investigated the role of hypoxia in PC generation. Hypoxia increases the generation of plasmablasts (PBs) starting from memory B cells, by increasing cell cycle and division number. Reactome analysis demonstrated a significant enrichment of genes involved in HIF1α and HIF2α transcription factor n ...[more]