Ontology highlight
ABSTRACT:
SUBMITTER: Pogorelyy MV
PROVIDER: S-EPMC5500008 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Pogorelyy Mikhail V MV Elhanati Yuval Y Marcou Quentin Q Sycheva Anastasiia L AL Komech Ekaterina A EA Nazarov Vadim I VI Britanova Olga V OV Chudakov Dmitriy M DM Mamedov Ilgar Z IZ Lebedev Yury B YB Mora Thierry T Walczak Aleksandra M AM
PLoS computational biology 20170706 7
The diversity of T-cell receptors recognizing foreign pathogens is generated through a highly stochastic recombination process, making the independent production of the same sequence rare. Yet unrelated individuals do share receptors, which together constitute a "public" repertoire of abundant clonotypes. The TCR repertoire is initially formed prenatally, when the enzyme inserting random nucleotides is downregulated, producing a limited diversity subset. By statistically analyzing deep sequencin ...[more]