MUC1: a multifaceted oncoprotein with a key role in cancer progression.
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ABSTRACT:
SUBMITTER: Nath S
PROVIDER: S-EPMC5500204 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Publications
MUC1: a multifaceted oncoprotein with a key role in cancer progression.
Nath Sritama S Mukherjee Pinku P
Trends in molecular medicine 20140322 6
The transmembrane glycoprotein Mucin 1 (MUC1) is aberrantly glycosylated and overexpressed in a variety of epithelial cancers, and plays a crucial role in progression of the disease. Tumor-associated MUC1 differs from the MUC1 expressed in normal cells with regard to its biochemical features, cellular distribution, and function. In cancer cells, MUC1 participates in intracellular signal transduction pathways and regulates the expression of its target genes at both the transcriptional and post-tr ...[more]
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