Ontology highlight
ABSTRACT:
SUBMITTER: Cho KH
PROVIDER: S-EPMC5500206 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Cho Kyung Ho KH Ribeiro Orquidea O Du Yang Y Tikhonova Elena E Mortensen Jonas S JS Markham Kelsey K Hariharan Parameswaran P Loland Claus J CJ Guan Lan L Kobilka Brian K BK Byrne Bernadette B Chae Pil Seok PS
Chemistry (Weinheim an der Bergstrasse, Germany) 20161117 52
Detergents serve as useful tools for membrane protein structural and functional studies. Their amphipathic nature allows detergents to associate with the hydrophobic regions of membrane proteins whilst maintaining the proteins in aqueous solution. However, widely used conventional detergents are limited in their ability to maintain the structural integrity of membrane proteins and thus there are major efforts underway to develop novel agents with improved properties. We prepared mesitylene-cored ...[more]