Ontology highlight
ABSTRACT:
SUBMITTER: Gallardo G
PROVIDER: S-EPMC5500436 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Gallardo Gilbert G Holtzman David M DM
Cold Spring Harbor perspectives in medicine 20171003 10
The astonishing findings that active and passive immunization against amyloid-β (Aβ) in mouse models of Alzheimer's disease (AD) dramatically decreased amyloid burden led to a rapid initiation of human clinical trials with much enthusiasm. However, methodological issues and adverse effects relating to these clinical trials arose, challenging the effectiveness and safety of these reagents. Efforts are now underway to develop safer immunotherapeutic approaches toward Aβ and the treatment of indivi ...[more]