MiR-320a as a Potential Novel Circulating Biomarker of Arrhythmogenic CardioMyopathy.

ABSTRACT: Diagnosis of Arrhythmogenic CardioMyopathy (ACM) is challenging and often late after disease onset. No circulating biomarkers are available to date. Given their involvement in several cardiovascular diseases, plasma microRNAs warranted investigation as potential non-invasive diagnostic tools in ACM. We sought to identify circulating microRNAs differentially expressed in ACM with respect to Healthy Controls (HC) and Idiopathic Ventricular Tachycardia patients (IVT), often in differential diagnosis. ACM and HC subjects were screened for plasmatic expression of 377 microRNAs and validation was performed in 36 ACM, 53 HC, 21 IVT. Variable importance in data partition was estimated through Random Forest analysis and accuracy by Receiver Operating Curves. Plasmatic miR-320a showed 0.53?±?0.04 fold expression difference in ACM vs. HC (p?

SUBMITTER: Sommariva E 

PROVIDER: S-EPMC5500514 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature