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Smart, programmable and responsive injectable hydrogels for controlled release of cargo osteoporosis drugs.

ABSTRACT: Easy-to-prepare drug delivery systems, based on smart, silica gels have been synthesized, characterized, and studied as hosts in the controlled release of bisphosphonates. They exhibit variable release rates and final % release, depending on the nature of bisphosphonate (side-chain length, hydro-philicity/-phobicity, water-solubility), cations present, pH and temperature. These gels are robust, injectable, re-loadable and re-usable.

SUBMITTER: Papathanasiou KE

PROVIDER: S-EPMC5500573 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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Smart, programmable and responsive injectable hydrogels for controlled release of cargo osteoporosis drugs.

Papathanasiou Konstantinos E KE Turhanen Petri P Brückner Stephan I SI Brunner Eike E Demadis Konstantinos D KD

Scientific reports 20170706 1

Easy-to-prepare drug delivery systems, based on smart, silica gels have been synthesized, characterized, and studied as hosts in the controlled release of bisphosphonates. They exhibit variable release rates and final % release, depending on the nature of bisphosphonate (side-chain length, hydro-philicity/-phobicity, water-solubility), cations present, pH and temperature. These gels are robust, injectable, re-loadable and re-usable. ...[more]

PMID: 28684783

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