Ontology highlight
ABSTRACT:
SUBMITTER: Thomas JM
PROVIDER: S-EPMC5501306 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
BioEssays : news and reviews in molecular, cellular and developmental biology 20170220 4
Deamination of adenosine in RNA to form inosine has wide ranging consequences on RNA function including amino acid substitution to give proteins not encoded in the genome. What determines which adenosines in an mRNA are subject to this modification reaction? The answer lies in an understanding of the mechanism and substrate recognition properties of adenosine deaminases that act on RNA (ADARs). Our recent publication of X-ray crystal structures of the human ADAR2 deaminase domain bound to RNA ed ...[more]