Ontology highlight
ABSTRACT:
SUBMITTER: Bolkan SS
PROVIDER: S-EPMC5501395 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Bolkan Scott S SS Stujenske Joseph M JM Parnaudeau Sebastien S Spellman Timothy J TJ Rauffenbart Caroline C Abbas Atheir I AI Harris Alexander Z AZ Gordon Joshua A JA Kellendonk Christoph C
Nature neuroscience 20170503 7
The mediodorsal thalamus (MD) shares reciprocal connectivity with the prefrontal cortex (PFC), and decreased MD-PFC connectivity is observed in schizophrenia patients. Patients also display cognitive deficits including impairments in working memory, but a mechanistic link between thalamo-prefrontal circuit function and working memory is missing. Using pathway-specific inhibition, we found directional interactions between mouse MD and medial PFC (mPFC), with MD-to-mPFC supporting working memory m ...[more]