Ontology highlight
ABSTRACT:
SUBMITTER: Tiburcy M
PROVIDER: S-EPMC5501412 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Tiburcy Malte M Hudson James E JE Balfanz Paul P Schlick Susanne S Meyer Tim T Chang Liao Mei-Ling ML Levent Elif E Raad Farah F Zeidler Sebastian S Wingender Edgar E Riegler Johannes J Wang Mouer M Gold Joseph D JD Kehat Izhak I Wettwer Erich E Ravens Ursula U Dierickx Pieterjan P van Laake Linda W LW Goumans Marie Jose MJ Khadjeh Sara S Toischer Karl K Hasenfuss Gerd G Couture Larry A LA Unger Andreas A Linke Wolfgang A WA Araki Toshiyuki T Neel Benjamin B Keller Gordon G Gepstein Lior L Wu Joseph C JC Zimmermann Wolfram-Hubertus WH
Circulation 20170206 19
<h4>Background</h4>Advancing structural and functional maturation of stem cell-derived cardiomyocytes remains a key challenge for applications in disease modeling, drug screening, and heart repair. Here, we sought to advance cardiomyocyte maturation in engineered human myocardium (EHM) toward an adult phenotype under defined conditions.<h4>Methods</h4>We systematically investigated cell composition, matrix, and media conditions to generate EHM from embryonic and induced pluripotent stem cell-der ...[more]