Unknown

Dataset Information

0

Coronary artery disease-associated genetic variants and biomarkers of inflammation.


ABSTRACT: Genetic constitution and inflammation both contribute to development of coronary artery disease (CAD). Several CAD-associated single-nucleotide polymorphisms (SNPs) have recently been identified, but their functions are largely unknown. We investigated the associations between CAD-associated SNPs and five CAD-related inflammatory biomarkers.We genotyped 45 CAD-associated SNPs in 701 stable CAD patients in whom levels of high-sensitivity C-reactive protein (hsRCP), interleukin-6, calprotectin, fibrinogen and complement component 3 levels had previously been measured. A genetic risk score was calculated to assess the combined risk associated with all the genetic variants. A multiple linear regression model was used to assess associations between the genetic risk score, single SNPs, and the five inflammatory biomarkers.The minor allele (G) (CAD risk allele) of rs2075650 (TOMM40/APOE) was associated with lower levels of high-sensitivity C-reactive protein (effect per risk allele: -0.37 mg/l [95%CI -0.56 to -0.18 mg/l]). The inflammatory markers tested showed no association with the remaining 44 SNPs or with the genetic risk score.In stable CAD patients, the risk allele of a common CAD-associated marker at the TOMM40/APOE locus was associated with lower hsCRP levels. No other genetic variants or the combined effect of all variants were associated with the five inflammatory biomarkers.

SUBMITTER: Christiansen MK 

PROVIDER: S-EPMC5501546 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

altmetric image

Publications


<h4>Introduction</h4>Genetic constitution and inflammation both contribute to development of coronary artery disease (CAD). Several CAD-associated single-nucleotide polymorphisms (SNPs) have recently been identified, but their functions are largely unknown. We investigated the associations between CAD-associated SNPs and five CAD-related inflammatory biomarkers.<h4>Methods</h4>We genotyped 45 CAD-associated SNPs in 701 stable CAD patients in whom levels of high-sensitivity C-reactive protein (hs  ...[more]

Similar Datasets

2021-01-11 | GSE109068 | GEO
| PRJNA429566 | ENA
| S-EPMC6068195 | biostudies-literature
| S-EPMC6796635 | biostudies-literature
2022-09-28 | GSE189300 | GEO
| S-EPMC4536952 | biostudies-literature
| S-EPMC4854982 | biostudies-literature
| S-EPMC7066794 | biostudies-literature
| S-EPMC6364925 | biostudies-literature
| S-EPMC5831297 | biostudies-other