Ontology highlight
ABSTRACT:
SUBMITTER: Shooshtari P
PROVIDER: S-EPMC5501874 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Shooshtari Parisa P Huang Hailiang H Cotsapas Chris C
American journal of human genetics 20170701 1
Genome-wide association studies in autoimmune and inflammatory diseases (AID) have uncovered hundreds of loci mediating risk. These associations are preferentially located in non-coding DNA regions and in particular in tissue-specific DNase I hypersensitivity sites (DHSs). While these analyses clearly demonstrate the overall enrichment of disease risk alleles on gene regulatory regions, they are not designed to identify individual regulatory regions mediating risk or the genes under their contro ...[more]