The effects of the location of cancer stem cell marker CD133 on the prognosis of hepatocellular carcinoma patients.

ABSTRACT:

Background

CD133 (prominin-1) is widely believed to be a cancer stem cell marker in various solid tumor types, and CD133 has been correlated with tumor-initiating capacity. Recently, the nuclear location of CD133 expression in tumors has been discussed, but hepatocellular carcinoma (HCC) has not been included in these discussions. The goal of this study was to investigate the location of CD133 expression in HCC and this location's potential value as a prognostic indicator of survival in patients with HCC.

Methods

We enrolled 119 cancerous tissues and pair-matched adjacent normal liver tissue from HCC patients. These tissues were obtained immediately after operation, and tissue microarrays were subsequently constructed. The expression of CD133 was measured by immunohistochemi

SUBMITTER: Chen YL 

PROVIDER: S-EPMC5501948 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature