Ontology highlight
ABSTRACT:
SUBMITTER: Aziz HR
PROVIDER: S-EPMC5502124 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Aziz Hannah R HR Singleton Daniel A DA
Journal of the American Chemical Society 20170411 16
Reactions that involve a combination of proton transfer and heavy-atom bonding changes are normally categorized by whether the proton transfer is occurring during the rate-limiting step, as in the distinction between general and specific acid-base catalysis. The experimental and computational study here of a β-ketoacid decarboxylation shows how the distinction between the two mechanisms breaks down near its border due to the differing time scales for proton versus heavy-atom motion. Isotope effe ...[more]