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Post hoc analyses of East Asian patients from the randomized placebo-controlled PREVAIL trial of enzalutamide in patients with chemotherapy-naive, metastatic castration-resistant prostate cancer.


ABSTRACT: Enzalutamide is an androgen receptor (AR) inhibitor that acts on different steps in the AR signaling pathway. In PREVAIL, an international, phase III, double-blind, placebo-controlled trial, enzalutamide significantly reduced the risk of radiographic progression by 81% (hazard ratio [HR], 0.19; P?

SUBMITTER: Kim CS 

PROVIDER: S-EPMC5502144 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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Post hoc analyses of East Asian patients from the randomized placebo-controlled PREVAIL trial of enzalutamide in patients with chemotherapy-naïve, metastatic castration-resistant prostate cancer.

Kim Choung Soo CS   Choi Young Deuk YD   Lee Sang Eun SE   Lee Hyun Moo HM   Ueda Takeshi T   Yonese Junji J   Fukagai Takashi T   Chiong Edmund E   Lau Weber W   Abhyankar Sarang S   Theeuwes Ad A   Tombal Bertrand B   Beer Tomasz M TM   Kimura Go G  

Medicine 20170701 27


<h4>Background</h4>Enzalutamide is an androgen receptor (AR) inhibitor that acts on different steps in the AR signaling pathway. In PREVAIL, an international, phase III, double-blind, placebo-controlled trial, enzalutamide significantly reduced the risk of radiographic progression by 81% (hazard ratio [HR], 0.19; P < .0001) and reduced the risk of death by 29% (HR, 0.71; P < .0001) compared with placebo in chemotherapy-naïve men with metastatic castration-resistant prostate cancer.<h4>Methods</h  ...[more]

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