Ontology highlight
ABSTRACT:
SUBMITTER: Monda KL
PROVIDER: S-EPMC5502543 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Monda Keri L KL North Kari E KE Hunt Steven C SC Rao D C DC Province Michael A MA Kraja Aldi T AT
Endocrine, metabolic & immune disorders drug targets 20100601 2
In this review, we discuss the genetic architecture of obesity and the metabolic syndrome, highlighting recent advances in identifying genetic variants and loci responsible for a portion of the variation in components of the metabolic syndrome, namely, adiposity traits, serum HDL and triglycerides, blood pressure, and glycemic traits. We focus particularly on recent progress from large-scale genome-wide association studies (GWAS), by detailing their successes and how lessons learned can pave the ...[more]