Ontology highlight
ABSTRACT:
SUBMITTER: Epeldegui M
PROVIDER: S-EPMC5502768 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Epeldegui Marta M Martínez-Maza Otoniel O
Forum on immunopathological diseases and therapeutics 20150101 1-2
HIV infection is associated with a greatly elevated risk for the development of non-Hodgkin lymphoma (NHL), which while diminished, remains elevated in the highly active antiretroviral therapy (HAART) era. Chronic B cell activation, driven by contact with HIV virions, B cell-stimulatory cytokines, viruses (EBV, HPV, HCV), and by high levels of antigenic stimulation occurs in HIV infected persons, and it is seen at even higher levels in those who go on to develop AIDS-NHL. Evidence from multiple ...[more]