Peripheral Neutrophil to Lymphocyte Ratio Improves Prognostication in Colon Cancer.

ABSTRACT:

Background

We studied the role of peripheral neutrophil to lymphocyte ratio (NLR) on survival outcomes in colon and rectal cancer to determine if its inclusion improved prognostication within existing staging systems.

Patients and methods

Disease-free (DFS) and overall survival (OS) hazard ratios (HRs) of pretreatment NLR were calculated for 2536 patients with stage I to III colon or rectal cancer and adjusted for age, positive/total number of nodes, T stage, and grade. The association of NLR with clinicopathologic features and survival was evaluated and compared with the American Joint Committee on cancer (AJCC) TNM staging and Memorial Sloan Kettering Cancer Center (MSKCC) models.

Results

High NLR was significantly associated with worse DFS (HR, 1.36; 95% confidence

SUBMITTER: Rashtak S 

PROVIDER: S-EPMC5503192 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature